Highly skilled practitioners, incredible experience and signature method developed by Founder Megan Kozak RN CANSmake The Pout Clinic the best Botox clinic Toronto. The effects of Botox ® comes in stages. As such, you will observe slight improvements after 48 to 72 hours with major changes observed after 14 days. These results will be present for about 3 to 4 months after which you are advised to visit the clinic again.The Pout Clinic believes in micro treatments and offers an exclusive membership that will ensure you are always looking your best 24/7, 365.